ORIGINAL ARTICLES

Correlation of quantitative MRI parameters with neurological outcome in acute cervical spinal cord injury

Mesi Mathew¹, Wilfred C Mezue², Mark C Chikani², Abdullahi O Jimoh¹, Enoch O Uche², Musa B Mathew³

¹ Surgery Department, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
²Surgery Department, University of Nigeria Teaching Hospital, Enugu, Nigeria
³General Hospital, Hadejia, Jigawa, Nigeria

Correspondence Address:
Dr. Mesi Mathew
Division of Neurosurgery, Ahmadu Bello University Teaching Hospital, Zaria Nigeria

Source of Support: None
Conflict of Interest: None

Background: The unbearable morbidity and significant mortality associated with traumatic cervical spine injuries (T-CSIs) have been complicated by difficulties in outcome prediction.

Objectives: This study aims to determine the correlation between quantitative magnetic resonance imaging (MRI) parameters and neurological outcome among patients with acute T-CSI.

Materials and Methods: This is a prospective study in which patients with T-CSI were recruited over a 12-month period. ASIA Impairment Scale (AIS) at admission, 6 weeks, and 3 months was assessed. Mean spinal cord compression (MSCC), mean canal compromise (MCC), and length of lesion (LOL) were calculated from MRI at admission, and correlation with neurological severity and outcome was determined. The data were analysed using SPSS version 21. A P-value of less than 0.05 was considered significant for associations.

Results: Sixty-nine patients were enrolled comprising 55 males and 14 females giving a male-female ratio of 4.9:1. Their ages ranged from 18 to 74 years with a mean age of 40.2?±?15.1 years. Injuries were ASIA A in 55.1% and ASIA E in 7.2% on admission. The mean MSCC, MCC, and LOL were higher for ASIA A and B and lowest in ASIA E injuries. Patients with good AIS (D and E) had significantly lower MSCC on admission (P = 0.032) and at 6 weeks (P = 0.000), and the LOL was also lower on admission (P = 0.000), at 6 weeks (P = 0.006), and at 3 months (P = 0.007). None of MRI parameters predicted outcome. Conclusion: The MSCC, MCC, and LOL correlate with T-CSI severity but were not sufficient to predict outcome.